Outcomes

The desired outcomes from the CMISS redevelopment project and people interested in them.

• Fully coupled electromechanical simulations in a full ventricular geometry (Andre, Peter).
• Real time solution of the bidomain equations using a physiologically realistic cellular model in a full ventricular geometry (Andre).
• Real time interactive volume rendering (Shane, Andre, Peter, Jack, Merryn).
• Intuitive user interface to full heart simulations (Andre).
• Seamless integration of images into modelling and visualisation framework, with appropriate and flexible image processing functionality (Greg, Merryn).
• Simultaneous solution of interdependent (iterative, not explicitly coupled) ventilation distribution, perfusion, gas exchange, and soft tissue mechanics (Merryn).
• micro-structural models of (discrete?) structure and mechanics of collagen/myocytes, feeding into mechanical properties of macro-scale (continuum) models (Martyn).
• detailed biophysical electrophysiology models used to determine macro-scale properties of lower-dimensional models appropriate for large scale simulations of electro-mechanics (Martyn, Andre).

In addition, the computational modelling code would have the following features:

• It is easily extended to new equations and domains (Karl, Andre).
• Source code is easily understandable (Karl, Andre).
• The computation and memory intensive components are fast and efficient (Karl, Andre).
• A modular design with efficient memory use (Greg, Merryn, Andre).